1973 – Study ~ ANTI-EDEMA AND ANALGESIC PROPERTIES OF Δ9-TETRAHYDROCANNABINOL (THC).

2001 – Study ~ Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints.

2003 – Study ~ Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.

2004 – Study ~ A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.

2005 – Study ~ Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials.

2006 – Study Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.

2006 – Study ~ SAFETY AND TOLERABILITY OF LONG-TERM TREATMENT WITH A CANNABIS-BASED MEDICINE (SATIVEX) IN PATIENTS WITH RHEUMATOID ARTHRITIS.

2007 – Study ~ Arthritis and pain. Future targets to control osteoarthritis pain.

2007 – Study ~ INHIBITORY EFFECT OF CANNABINOID AGONISTS ON CYTOKINE PRODUCTION IN HUMAN OSTEOARTRITHIC AND RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES.

2008 – Study ~ Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis.

2008 – Study ~ In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints.

2008 – Study Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.

2008 – Study CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.

2008 – Study ~ Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid.

2008 – Study ~ Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells.

2009 – Study Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.

2009 – Study Cannabinoids as novel anti-inflammatory drugs.

2010 – Study Tissue Engineering of Cartilage; Can Cannabinoids Help?

2010 – Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.

2010 – Study Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.

2010 – Study ~ Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.

2010 – Study ~ Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.

2011 – Study Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials.

2011 – Study ~ Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

2011 – Study ~ The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.

2011 – Study ~ Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.

2012 – Study Platelet-rich plasma loaded hydrogel scaffold enhances chondrogenic differentiation and maturation with up-regulation of CB1 and CB2.

2012 – Study ~ Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level.

2012 – Study ~ Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.

2012 – Study ~ Cannabinoids: novel therapies for arthritis?

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