1. Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine.
Bergamaschi MM, Barnes A, Queiroz RH, Hurd YL, Huestis MA.
Anal Bioanal Chem. 2013 Mar 15. [Epub ahead of print]
PMID: 23494274 [PubMed – as supplied by publisher]
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2. Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy.
Casarejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, de Yebenes JG, Mena MA.
J Alzheimers Dis. 2013 Mar 11. [Epub ahead of print]
PMID: 23478312 [PubMed – as supplied by publisher]
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3. Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses.
Sylantyev S, Jensen TP, Ross RA, Rusakov DA.
Proc Natl Acad Sci U S A. 2013 Mar 7. [Epub ahead of print]
PMID: 23472002 [PubMed – as supplied by publisher] Free Article
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4. Industrial hemp decreases intestinal motility stronger than indian hemp in mice.
Sabo A, Horvat O, Stilinovic N, Berenji J, Vukmirovic S.
Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):486-90.
PMID: 23467947 [PubMed – in process]
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5. A GPR18-based signaling system regulates IOP in murine eye.
Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A.
Br J Pharmacol. 2013 Mar 5. doi: 10.1111/bph.12136. [Epub ahead of print]
PMID: 23461720 [PubMed – as supplied by publisher]
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6. Cannabis, psychosis and the thalamus: Some new theoretical concepts and insights.
Vukadinovic Z, Herman MS, Rosenzweig I.
Neurosci Biobehav Rev. 2013 Feb 28. doi:pii: S0149-7634(13)00049-3. 10.1016/j.neubiorev.2013.02.013. [Epub ahead of print]
PMID: 23458778 [PubMed – as supplied by publisher]
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7. The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig.
Dudášová A, Keir SD, Parsons ME, Molleman A, Page CP.
Pulm Pharmacol Ther. 2013 Feb 18. doi:pii: S1094-5539(13)00059-X. 10.1016/j.pupt.2013.02.002. [Epub ahead of print]
PMID: 23428645 [PubMed – as supplied by publisher]
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8. [Marihuana and cannobinoids as medicaments].
Tkaczyk M, Florek E, Piekoszewski W.
Przegl Lek. 2012;69(10):1095-7. Polish.
PMID: 23421098 [PubMed – in process]
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9. Cannabis and Δ(9)-tetrahydrocannabinol (THC) for weight loss?
Le Foll B, Trigo JM, Sharkey KA, Strat YL.
Med Hypotheses. 2013 Feb 11. doi:pii: S0306-9877(13)00042-X. 10.1016/j.mehy.2013.01.019. [Epub ahead of print]
PMID: 23410498 [PubMed – as supplied by publisher]
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10. A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany.
Flachenecker P.
Expert Rev Neurother. 2013 Feb;13(3 Suppl 1):15-9. doi: 10.1586/ern.13.1.
PMID: 23369055 [PubMed – in process]
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11. Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain.
García-Merino A.
Expert Rev Neurother. 2013 Feb;13(3 Suppl 1):9-13. doi: 10.1586/ern.13.4.
PMID: 23369054 [PubMed – in process]
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12. Development and validation of an LC-MS/MS method for quantification of Δ9-tetrahydrocannabinolic acid A (THCA-A), THC, CBN and CBD in hair.
Roth N, Moosmann B, Auwärter V.
J Mass Spectrom. 2013 Feb;48(2):227-33. doi: 10.1002/jms.3152.
PMID: 23378095 [PubMed – in process]
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13. Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme.
Hernán Pérez de la Ossa D, Lorente M, Gil-Alegre ME, Torres S, García-Taboada E, Aberturas Mdel R, Molpeceres J, Velasco G, Torres-Suárez AI.
PLoS One. 2013;8(1):e54795. doi: 10.1371/journal.pone.0054795. Epub 2013 Jan 22.
PMID: 23349970 [PubMed – in process] Free PMC Article
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14. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.
Chagas MH, Crippa JA, Zuardi AW, Hallak JE, Machado-de-Sousa JP, Hirotsu C, Maia L, Tufik S, Andersen ML.
J Psychopharmacol. 2013 Mar;27(3):312-6. doi: 10.1177/0269881112474524. Epub 2013 Jan 23.
PMID: 23343597 [PubMed – in process]
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15. Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19.
Jiang R, Yamaori S, Okamoto Y, Yamamoto I, Watanabe K.
Drug Metab Pharmacokinet. 2013 Jan 15. [Epub ahead of print]
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16. Cannabidiol enhances consolidation of explicit fear extinction in humans.
Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ.
Psychopharmacology (Berl). 2013 Jan 10. [Epub ahead of print]
PMID: 23307069 [PubMed – as supplied by publisher]
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17. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
Campos AC, Ortega Z, Palazuelos J, Fogaça MV, Aguiar DC, Díaz-Alonso J, Ortega-Gutiérrez S, Vázquez-Villa H, Moreira FA, Guzmán M, Galve-Roperh I, Guimarães FS.
Int J Neuropsychopharmacol. 2013 Jan 9:1-13. [Epub ahead of print]
PMID: 23298518 [PubMed – as supplied by publisher]
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18. Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR.
Happyana N, Agnolet S, Muntendam R, Van Dam A, Schneider B, Kayser O.
Phytochemistry. 2013 Mar;87:51-9. doi: 10.1016/j.phytochem.2012.11.001. Epub 2012 Dec 29.
PMID: 23280038 [PubMed – in process]
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19. Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.
Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.
Genes Cancer. 2012 Jul;3(7-8):512-20. doi: 10.1177/1947601912466556.
PMID: 23264851 [PubMed] Free PMC Article
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20. Endocannabinoid system and mood disorders: Priming a target for new therapies.
Micale V, Di Marzo V, Sulcova A, Wotjak CT, Drago F.
Pharmacol Ther. 2013 Apr;138(1):18-37. doi: 10.1016/j.pharmthera.2012.12.002. Epub 2012 Dec 20.
PMID: 23261685 [PubMed – in process]
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21. Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target.
Soroceanu L, Murase R, Limbad C, Singer E, Allison J, Adrados I, Kawamura R, Pakdel A, Fukuyo Y, Nguyen D, Khan S, Arauz R, Yount GL, Moore DH, Desprez PY, McAllister SD.
Cancer Res. 2013 Mar 1;73(5):1559-69. doi: 10.1158/0008-5472.CAN-12-1943. Epub 2012 Dec 13.
PMID: 23243024 [PubMed – in process]
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22. What place for ▾ cannabis extract in MS?
[No authors listed]
Drug Ther Bull. 2012 Dec;50(12):141-4. doi: 10.1136/dtb.2012.11.0150.
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23. Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse.
Al Saabi A, Allorge D, Sauvage FL, Tournel G, Gaulier JM, Marquet P, Picard N.
Drug Metab Dispos. 2013 Mar;41(3):568-74. doi: 10.1124/dmd.112.047878. Epub 2012 Dec 10.
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24. COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.
Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, Hinz B.
Mol Cancer Ther. 2013 Jan;12(1):69-82. doi: 10.1158/1535-7163.MCT-12-0335. Epub 2012 Dec 7.
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25. Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel.
Barro-Soria R, Stindl J, Müller C, Foeckler R, Todorov V, Castrop H, Strauß O.
PLoS One. 2012;7(11):e49624. doi: 10.1371/journal.pone.0049624. Epub 2012 Nov 20.
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26. A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.
Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe S.
J Neurol. 2012 Nov 21. [Epub ahead of print]
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27. A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray.
Stott CG, White L, Wright S, Wilbraham D, Guy GW.
Eur J Clin Pharmacol. 2012 Nov 22. [Epub ahead of print]
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28. Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice.
Karmaus PW, Wagner JG, Harkema JR, Kaminski NE, Kaplan BL.
J Immunotoxicol. 2012 Nov 23. [Epub ahead of print]
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29. Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration?
Lee D, Karschner EL, Milman G, Barnes AJ, Goodwin RS, Huestis MA.
Drug Alcohol Depend. 2012 Nov 9. doi:pii: S0376-8716(12)00411-5. 10.1016/j.drugalcdep.2012.10.011. [Epub ahead of print]
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30. An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics.
Johnson JR, Lossignol D, Burnell-Nugent M, Fallon MT.
J Pain Symptom Manage. 2012 Nov 7. doi:pii: S0885-3924(12)00439-3. 10.1016/j.jpainsymman.2012.07.014. [Epub ahead of print]
PMID: 23141881 [PubMed – as supplied by publisher]
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31. Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test.
Almeida V, Levin R, Peres FF, Niigaki ST, Calzavara MB, Zuardi AW, Hallak JE, Crippa JA, Abílio VC.
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Mar 5;41:30-5. doi: 10.1016/j.pnpbp.2012.10.024. Epub 2012 Nov 2.
PMID: 23127569 [PubMed – in process]
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32. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation.
Bolognini D, Rock E, Cluny N, Cascio M, Limebeer C, Duncan M, Stott C, Javid F, Parker L, Pertwee R.
Br J Pharmacol. 2013 Mar;168(6):1456-1470. doi: 10.1111/bph.12043.
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33. Medical use of cannabis. Cannabidiol: a new light for schizophrenia?
Deiana S.
Drug Test Anal. 2013 Jan;5(1):46-51. doi: 10.1002/dta.1425. Epub 2012 Oct 25.
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34. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.
Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS.
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3364-78. doi: 10.1098/rstb.2011.0389.
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35. Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities.
Pertwee RG.
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3353-63. doi: 10.1098/rstb.2011.0381.
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36. N-Arachidonyl glycine does not activate G protein-coupled receptor 18 signaling via canonical pathways.
Lu VB, Puhl HL 3rd, Ikeda SR.
Mol Pharmacol. 2013 Jan;83(1):267-82. doi: 10.1124/mol.112.081182. Epub 2012 Oct 25.
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37. Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability.
O’Brien LD, Wills KL, Segsworth B, Dashney B, Rock EM, Limebeer CL, Parker LA.
Pharmacol Biochem Behav. 2013 Jan;103(3):597-602. doi: 10.1016/j.pbb.2012.10.008. Epub 2012 Oct 25.
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38. Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report.
Crippa JA, Hallak JE, Machado-de-Sousa JP, Queiroz RH, Bergamaschi M, Chagas MH, Zuardi AW.
J Clin Pharm Ther. 2013 Apr;38(2):162-4. doi: 10.1111/jcpt.12018. Epub 2012 Oct 24.
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39. Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis.
Barichello T, Ceretta RA, Generoso JS, Moreira AP, Simões LR, Comim CM, Quevedo J, Vilela MC, Zuardi AW, Crippa JA, Teixeira AL.
Eur J Pharmacol. 2012 Dec 15;697(1-3):158-64. doi: 10.1016/j.ejphar.2012.09.053. Epub 2012 Oct 16.
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40. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents.
Nabissi M, Morelli MB, Santoni M, Santoni G.
Carcinogenesis. 2013 Jan;34(1):48-57. doi: 10.1093/carcin/bgs328. Epub 2012 Oct 18.
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41. A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray.
Stott CG, White L, Wright S, Wilbraham D, Guy GW.
Eur J Clin Pharmacol. 2012 Oct 4. [Epub ahead of print]
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42. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.
Englund A, Morrison PD, Nottage J, Hague D, Kane F, Bonaccorso S, Stone JM, Reichenberg A, Brenneisen R, Holt D, Feilding A, Walker L, Murray RM, Kapur S.
J Psychopharmacol. 2013 Jan;27(1):19-27. doi: 10.1177/0269881112460109. Epub 2012 Oct 5.
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43. Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT(1A) receptor.
Gomes FV, Alves FH, Guimarães FS, Correa FM, Resstel LB, Crestani CC.
Eur Neuropsychopharmacol. 2012 Oct 4. doi:pii: S0924-977X(12)00271-4. 10.1016/j.euroneuro.2012.09.007. [Epub ahead of print]
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44. [Treatment of spasticity in multiple sclerosis: new perspectives regarding the use of cannabinoids].
Oreja-Guevara C.
Rev Neurol. 2012 Oct 1;55(7):421-30. Spanish.
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45. Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats.
Campos AC, de Paula Soares V, Carvalho MC, Ferreira FR, Vicente MA, Brandão ML, Zuardi AW, Zangrossi H Jr, Guimarães FS.
Psychopharmacology (Berl). 2013 Mar;226(1):13-24. doi: 10.1007/s00213-012-2878-7. Epub 2012 Sep 25.
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46. Distribution of free and conjugated cannabinoids in human bile samples.
Fabritius M, Staub C, Mangin P, Giroud C.
Forensic Sci Int. 2012 Nov 30;223(1-3):114-8. doi: 10.1016/j.forsciint.2012.08.013. Epub 2012 Sep 11.
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47. Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors.
Campos AC, Ferreira FR, Guimarães FS.
J Psychiatr Res. 2012 Nov;46(11):1501-10. doi: 10.1016/j.jpsychires.2012.08.012. Epub 2012 Sep 11.
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48. Direct analysis of cannabis samples by desorption atmospheric pressure photoionization-mass spectrometry.
Kauppila TJ, Flink A, Laakkonen UM, Aalberg L, Ketola RA.
Drug Test Anal. 2013 Mar;5(3):186-90. doi: 10.1002/dta.1412. Epub 2012 Sep 13.
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49. Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity.
Leussink VI, Husseini L, Warnke C, Broussalis E, Hartung HP, Kieseier BC.
Ther Adv Neurol Disord. 2012 Sep;5(5):255-66. doi: 10.1177/1756285612453972.
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50. A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis.
Granja AG, Carrillo-Salinas F, Pagani A, Gómez-Cañas M, Negri R, Navarrete C, Mecha M, Mestre L, Fiebich BL, Cantarero I, Calzado MA, Bellido ML, Fernandez-Ruiz J, Appendino G, Guaza C, Muñoz E.
J Neuroimmune Pharmacol. 2012 Dec;7(4):1002-16. doi: 10.1007/s11481-012-9399-3. Epub 2012 Sep 14.
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51. “The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB(1) and FAAH-independent mechanisms.”
Bosier B, Muccioli GG, Lambert DM.
Br J Pharmacol. 2012 Sep 12. doi: 10.1111/j.1476-5381.2012.02208.x. [Epub ahead of print]
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52. Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H.
Toxicol Lett. 2012 Nov 15;214(3):314-9. doi: 10.1016/j.toxlet.2012.08.029. Epub 2012 Sep 8.
PMID: 22963825 [PubMed – indexed for MEDLINE]
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53. Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis.
Podda G, Constantinescu CS.
Expert Opin Biol Ther. 2012 Nov;12(11):1517-31. doi: 10.1517/14712598.2012.721765. Epub 2012 Sep 7.
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54. Fast liquid chromatography/tandem mass spectrometry determination of cannabinoids in micro volume blood samples after dabsyl derivatization.
Lacroix C, Saussereau E.
J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 15;905:85-95. doi: 10.1016/j.jchromb.2012.08.006. Epub 2012 Aug 13.
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55. On-site test for cannabinoids in oral fluid.
Desrosiers NA, Lee D, Schwope DM, Milman G, Barnes AJ, Gorelick DA, Huestis MA.
Clin Chem. 2012 Oct;58(10):1418-25. Epub 2012 Aug 21.
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56. Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis.
Serpell MG, Notcutt W, Collin C.
J Neurol. 2013 Jan;260(1):285-95. doi: 10.1007/s00415-012-6634-z. Epub 2012 Aug 10.
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57. Cannabidiol treatment ameliorates ischemia/reperfusion renal injury in rats.
Fouad AA, Al-Mulhim AS, Jresat I.
Life Sci. 2012 Sep 17;91(7-8):284-92. doi: 10.1016/j.lfs.2012.07.030. Epub 2012 Aug 1.
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58. Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT(1A) receptors in the dorsal raphe nucleus.
Katsidoni V, Anagnostou I, Panagis G.
Addict Biol. 2013 Mar;18(2):286-96. doi: 10.1111/j.1369-1600.2012.00483.x. Epub 2012 Aug 2.
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59. Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington’s Disease: Role of CB(1) and CB(2) Receptors.
Valdeolivas S, Satta V, Pertwee RG, Fernández-Ruiz J, Sagredo O.
ACS Chem Neurosci. 2012 May 16;3(5):400-6. doi: 10.1021/cn200114w. Epub 2012 Feb 9.
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60. Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice.
Li K, Feng JY, Li YY, Yuece B, Lin XH, Yu LY, Li YN, Feng YJ, Storr M.
Pancreas. 2013 Jan;42(1):123-9. doi: 10.1097/MPA.0b013e318259f6f0.
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61. Towards the use of non-psychoactive cannabinoids for prostate cancer.
Pacher P.
Br J Pharmacol. 2013 Jan;168(1):76-8. doi: 10.1111/j.1476-5381.2012.02121.x.
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62. siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration.
McHugh D, Wager-Miller J, Page J, Bradshaw HB.
J Mol Signal. 2012 Jul 26;7(1):10. doi: 10.1186/1750-2187-7-10.
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63. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.
Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D.
Transl Psychiatry. 2012 Mar 20;2:e94. doi: 10.1038/tp.2012.15.
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64. The atypical cannabinoid o-1602: targets, actions, and the central nervous system.
Ashton JC.
Cent Nerv Syst Agents Med Chem. 2012 Sep;12(3):233-9.
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65. Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview.
Esposito G, Filippis DD, Cirillo C, Iuvone T, Capoccia E, Scuderi C, Steardo A, Cuomo R, Steardo L.
Phytother Res. 2012 Jul 20. doi: 10.1002/ptr.4781. [Epub ahead of print]
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66. CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells.
Arnold JC, Hone P, Holland ML, Allen JD.
Pharmacol Rep. 2012;64(3):751-7.
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67. New biocomposites based on bioplastic flax fibers and biodegradable polymers.
Wróbel-Kwiatkowska M, Czemplik M, Kulma A, Zuk M, Kaczmar J, Dymińska L, Hanuza J, Ptak M, Szopa J.
Biotechnol Prog. 2012 Sep-Oct;28(5):1336-46. doi: 10.1002/btpr.1599. Epub 2012 Aug 17.
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68. Simultaneous quantification of free and glucuronidated cannabinoids in human urine by liquid chromatography tandem mass spectrometry.
Scheidweiler KB, Desrosiers NA, Huestis MA.
Clin Chim Acta. 2012 Nov 20;413(23-24):1839-47. doi: 10.1016/j.cca.2012.06.034. Epub 2012 Jul 6.
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69. Comment on: “Anxiogenic-like effects of chronic cannabidiol administration in rats” (Elbatsh MM, Assareh N, Marsden CA, Kendall DA, Psychopharmacology 2012).
Gururajan A.
Psychopharmacology (Berl). 2012 Aug;222(4):725-6; author reply 727. doi: 10.1007/s00213-012-2780-3. Epub 2012 Jul 4. No abstract available.
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70. Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress.
Mecha M, Torrao AS, Mestre L, Carrillo-Salinas FJ, Mechoulam R, Guaza C.
Cell Death Dis. 2012 Jun 28;3:e331. doi: 10.1038/cddis.2012.71.
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71. Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.
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72. Cannabis derivatives therapy for a seronegative stiff-person syndrome: a case report.
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74. A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.
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76. Subjective and physiological effects of oromucosal sprays containing cannabinoids (nabiximols): potentials and limitations for psychosis research.
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78. Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers.
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81. Neural mechanisms for the cannabinoid modulation of cognition and affect in man: a critical review of neuroimaging studies.
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82. The yin and yang of cannabis-induced psychosis: the actions of Δ(9)-tetrahydrocannabinol and cannabidiol in rodent models of schizophrenia.
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83. Cannabinoid-like anti-inflammatory compounds from flax fiber.
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85. Sativex® in multiple sclerosis spasticity: a cost-effectiveness model.
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87. Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function.
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88. Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
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89. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
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90. Cannabidiol inhibits angiogenesis by multiple mechanisms.
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91. First systematic evaluation of the potency of Cannabis sativa plants grown in Albania.
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92. Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.
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93. Isomerization of cannabidiol and Δ9-tetrahydrocannabinol during positive electrospray ionization. In-source hydrogen/deuterium exchange experiments by flow injection hybrid quadrupole-time-of-flight mass spectrometry.
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94. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
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95. Involvement of a non-CB1/CB2 cannabinoid receptor in the aqueous humor outflow-enhancing effects of abnormal-cannabidiol.
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96. Poly-ε-caprolactone microspheres as a drug delivery system for cannabinoid administration: development, characterization and in vitro evaluation of their antitumoral efficacy.
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97. Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples.
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98. Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures.
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100. On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment.
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101. Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.
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102. Cannabidiol-induced apoptosis in murine microglial cells through lipid raft.
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104. Evaluation of the safety and tolerability profile of Sativex: is it reassuring enough?
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105. Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity.
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106. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.
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107. Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice.
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108. Cannabidiol as potential anticancer drug.
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109. Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats.
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110. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial.
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111. Chemiluminescence detection of cannabinoids and related compounds with acidic potassium permanganate.
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113. New pain drugs in pipeline, but challenges to usage remain.
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114. [The potential use of cannabidiol in the therapy of metabolic syndrome].
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115. Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice.
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116. Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects.
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117. Blurred boundaries: the therapeutics and politics of medical marijuana.
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118. Comparison of bulk and compound-specific δ13C isotope ratio analyses for the discrimination between cannabis samples.
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119. Production of identical retention times and mass spectra for {delta}9-tetrahydrocannabinol and cannabidiol following derivatization with trifluoracetic anhydride with 1,1,1,3,3,3-hexafluoroisopropanol*.
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120. Cannabinoids and metabolites in expectorated oral fluid following controlled smoked cannabis.
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121. Cannabinoids: novel medicines for the treatment of Huntington’s disease.
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124. Pharmacological interventions in the treatment of the acute effects of cannabis: a systematic review of literature.
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125. Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor.
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126. Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson’s disease.
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127. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.
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128. Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.
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129. Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing.
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130. Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.
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131. The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)).
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132. Cannabidiol affects the expression of genes involved in zinc homeostasis in BV-2 microglial cells.
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133. Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
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134. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
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135. Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.
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136. The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications.
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137. Cannabinoid hyperemesis syndrome.
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138. Safety and side effects of cannabidiol, a Cannabis sativa constituent.
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139. Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.
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140. Effect of cannabidiol on human gingival fibroblast extracellular matrix metabolism: MMP production and activity, and production of fibronectin and transforming growth factor β.
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141. Screening for Selective Ligands for GPR55 – Antagonists.
Heynen-Genel S, Dahl R, Shi S, Milan L, Hariharan S, Sergienko E, Hedrick M, Dad S, Stonich D, Su Y, Vicchiarelli M, Mangravita-Novo A, Smith LH, Chung TDY, Sharir H, Caron MG, Barak LS, Abood ME.
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142. Anxiogenic-like effects of chronic cannabidiol administration in rats.
ElBatsh MM, Assareh N, Marsden CA, Kendall DA.
Psychopharmacology (Berl). 2012 May;221(2):239-47. doi: 10.1007/s00213-011-2566-z. Epub 2011 Nov 15.
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143. [Cannabinoids for symptomatic therapy of multiple sclerosis].
Husseini L, Leussink VI, Warnke C, Hartung HP, Kieseier BC.
Nervenarzt. 2012 Jun;83(6):695-704. doi: 10.1007/s00115-011-3401-9. Review. German.
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144. [Does cannabis use lead to schizophrenia?].
Heekeren K.
Praxis (Bern 1994). 2011 Nov 2;100(22):1361-7. doi: 10.1024/1661-8157/a000714. Review. German.
PMID: 22048912 [PubMed – indexed for MEDLINE]
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145. Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects.
Marco EM, García-Gutiérrez MS, Bermúdez-Silva FJ, Moreira FA, Guimarães F, Manzanares J, Viveros MP.
Front Behav Neurosci. 2011;5:63. doi: 10.3389/fnbeh.2011.00063. Epub 2011 Oct 5.
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146. The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus.
Cluny NL, Naylor RJ, Whittle BA, Javid FA.
Arch Pharm Res. 2011 Sep;34(9):1509-17. doi: 10.1007/s12272-011-0913-6. Epub 2011 Oct 6.
PMID: 21975813 [PubMed – indexed for MEDLINE]
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147. Interaction between cannabidiol (CBD) and ∆(9)-tetrahydrocannabinol (THC): influence of administration interval and dose ratio between the cannabinoids.
Zuardi AW, Hallak JE, Crippa JA.
Psychopharmacology (Berl). 2012 Jan;219(1):247-9. doi: 10.1007/s00213-011-2495-x. Epub 2011 Sep 21. No abstract available.
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148. Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats.
Fouad AA, Jresat I.
Eur J Pharmacol. 2011 Nov 16;670(1):216-23. doi: 10.1016/j.ejphar.2011.08.048. Epub 2011 Sep 14.
PMID: 21930120 [PubMed – indexed for MEDLINE]
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149. Phytocannabinoids as novel therapeutic agents in CNS disorders.
Hill AJ, Williams CM, Whalley BJ, Stephens GJ.
Pharmacol Ther. 2012 Jan;133(1):79-97. doi: 10.1016/j.pharmthera.2011.09.002. Epub 2011 Sep 6. Review.
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150. Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm.
Uribe-Mariño A, Francisco A, Castiblanco-Urbina MA, Twardowschy A, Salgado-Rohner CJ, Crippa JA, Hallak JE, Zuardi AW, Coimbra NC.
Neuropsychopharmacology. 2012 Jan;37(2):412-21. doi: 10.1038/npp.2011.188. Epub 2011 Sep 14.
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151. Endocannabinoid system dysfunction in mood and related disorders.
Ashton CH, Moore PB.
Acta Psychiatr Scand. 2011 Oct;124(4):250-61. doi: 10.1111/j.1600-0447.2011.01687.x. Epub 2011 Mar 9. Review.
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152. Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury.
Kwiatkoski M, Guimarães FS, Del-Bel E.
Neurotox Res. 2012 Apr;21(3):271-80. doi: 10.1007/s12640-011-9273-8. Epub 2011 Sep 14.
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153. A placebo-controlled, parallel-group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex® (nabiximols).
Notcutt W, Langford R, Davies P, Ratcliffe S, Potts R.
Mult Scler. 2012 Feb;18(2):219-28. doi: 10.1177/1352458511419700. Epub 2011 Aug 30.
PMID: 21878454 [PubMed – indexed for MEDLINE]
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154. Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders.
Fagherazzi EV, Garcia VA, Maurmann N, Bervanger T, Halmenschlager LH, Busato SB, Hallak JE, Zuardi AW, Crippa JA, Schröder N.
Psychopharmacology (Berl). 2012 Feb;219(4):1133-40. doi: 10.1007/s00213-011-2449-3. Epub 2011 Aug 26.
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155. Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.
Hsiao YT, Yi PL, Li CL, Chang FC.
Neuropharmacology. 2012 Jan;62(1):373-84. doi: 10.1016/j.neuropharm.2011.08.013. Epub 2011 Aug 16.
PMID: 21867717 [PubMed – indexed for MEDLINE]
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156. Identification of recent cannabis use: whole-blood and plasma free and glucuronidated cannabinoid pharmacokinetics following controlled smoked cannabis administration.
Schwope DM, Karschner EL, Gorelick DA, Huestis MA.
Clin Chem. 2011 Oct;57(10):1406-14. doi: 10.1373/clinchem.2011.171777. Epub 2011 Aug 11.
PMID: 21836075 [PubMed – indexed for MEDLINE] Free Article
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157. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.
Rock EM, Bolognini D, Limebeer CL, Cascio MG, Anavi-Goffer S, Fletcher PJ, Mechoulam R, Pertwee RG, Parker LA.
Br J Pharmacol. 2012 Apr;165(8):2620-34. doi: 10.1111/j.1476-5381.2011.01621.x.
PMID: 21827451 [PubMed – indexed for MEDLINE]
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158. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
Yamaori S, Okamoto Y, Yamamoto I, Watanabe K.
Drug Metab Dispos. 2011 Nov;39(11):2049-56. doi: 10.1124/dmd.111.041384. Epub 2011 Aug 5.
PMID: 21821735 [PubMed – indexed for MEDLINE] Free Article
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159. Molecular analysis of genetic fidelity in Cannabis sativa L. plants grown from synthetic (encapsulated) seeds following in vitro storage.
Lata H, Chandra S, Techen N, Khan IA, ElSohly MA.
Biotechnol Lett. 2011 Dec;33(12):2503-8. doi: 10.1007/s10529-011-0712-7. Epub 2011 Jul 30.
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160. Cannabidiol-2′,6′-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro.
Takeda S, Hirayama A, Urata S, Mano N, Fukagawa K, Imamura M, Irii A, Kitajima S, Masuyama T, Nomiyama M, Tatei S, Tomita S, Kudo T, Noguchi M, Yamaguchi Y, Okamoto Y, Amamoto T, Fukunishi Y, Watanabe K, Omiecinski CJ, Aramaki H.
Biol Pharm Bull. 2011;34(8):1252-6.
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161. Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being.
Morgan CJ, Gardener C, Schafer G, Swan S, Demarchi C, Freeman TP, Warrington P, Rupasinghe I, Ramoutar A, Tan N, Wingham G, Lewis S, Curran HV.
Psychol Med. 2011 Jul 29:1-10. [Epub ahead of print]
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162. Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour.
Deiana S, Watanabe A, Yamasaki Y, Amada N, Arthur M, Fleming S, Woodcock H, Dorward P, Pigliacampo B, Close S, Platt B, Riedel G.
Psychopharmacology (Berl). 2012 Feb;219(3):859-73. doi: 10.1007/s00213-011-2415-0. Epub 2011 Jul 28.
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163. Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.
Granjeiro EM, Gomes FV, Guimarães FS, Corrêa FM, Resstel LB.
Pharmacol Biochem Behav. 2011 Oct;99(4):743-8. doi: 10.1016/j.pbb.2011.06.027. Epub 2011 Jul 12.
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164. Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure.
Szczesniak AM, Maor Y, Robertson H, Hung O, Kelly ME.
J Ocul Pharmacol Ther. 2011 Oct;27(5):427-35. doi: 10.1089/jop.2011.0041. Epub 2011 Jul 19.
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165. Cannabinoids in oral fluid following passive exposure to marijuana smoke.
Moore C, Coulter C, Uges D, Tuyay J, van der Linde S, van Leeuwen A, Garnier M, Orbita J Jr.
Forensic Sci Int. 2011 Oct 10;212(1-3):227-30. doi: 10.1016/j.forsciint.2011.06.019. Epub 2011 Jul 18.
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166. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo EB.
Br J Pharmacol. 2011 Aug;163(7):1344-64. doi: 10.1111/j.1476-5381.2011.01238.x. Review.
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167. Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability.
Alhamoruni A, Wright KL, Larvin M, O’Sullivan SE.
Br J Pharmacol. 2012 Apr;165(8):2598-610. doi: 10.1111/j.1476-5381.2011.01589.x.
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168. Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice.
Ward SJ, Ramirez MD, Neelakantan H, Walker EA.
Anesth Analg. 2011 Oct;113(4):947-50. doi: 10.1213/ANE.0b013e3182283486. Epub 2011 Jul 7.
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169. Direct quantification of cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography-tandem mass spectrometry.
Schwope DM, Scheidweiler KB, Huestis MA.
Anal Bioanal Chem. 2011 Sep;401(4):1273-83. doi: 10.1007/s00216-011-5197-7. Epub 2011 Jul 5.
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170. Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation.
De Petrocellis L, Orlando P, Moriello AS, Aviello G, Stott C, Izzo AA, Di Marzo V.
Acta Physiol (Oxf). 2012 Feb;204(2):255-66. doi: 10.1111/j.1748-1716.2011.02338.x. Epub 2011 Aug 12.
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171. Evaluate symptomatic therapy in MS: can clinical trials be fine-tuned?
Solaro C.
Eur J Neurol. 2011 Sep;18(9):1113-4. doi: 10.1111/j.1468-1331.2011.03425.x. Epub 2011 Jul 5. No abstract available.
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172. A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents.
Lin XH, Yuece B, Li YY, Feng YJ, Feng JY, Yu LY, Li K, Li YN, Storr M.
Neurogastroenterol Motil. 2011 Sep;23(9):862-e342. doi: 10.1111/j.1365-2982.2011.01742.x. Epub 2011 Jul 5.
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173. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.
Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K.
Life Sci. 2011 Aug 1;89(5-6):165-70. doi: 10.1016/j.lfs.2011.05.018. Epub 2011 Jun 16.
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174. The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives.
Marco EM, Laviola G.
J Psychopharmacol. 2012 Jan;26(1):150-63. doi: 10.1177/0269881111408459. Epub 2011 Jun 21. Review.
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175. The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.
Schuelert N, McDougall JJ.
Neurosci Lett. 2011 Aug 1;500(1):72-6. doi: 10.1016/j.neulet.2011.06.004. Epub 2011 Jun 13.
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176. Screening and quantitation of multiclass drugs of abuse and pharmaceuticals in hair by fast liquid chromatography electrospray time-of-flight mass spectrometry.
Domínguez-Romero JC, García-Reyes JF, Molina-Díaz A.
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 15;879(22):2034-42. doi: 10.1016/j.jchromb.2011.05.034. Epub 2011 May 30.
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177. Oral fluid cannabinoids in chronic, daily Cannabis smokers during sustained, monitored abstinence.
Lee D, Milman G, Barnes AJ, Goodwin RS, Hirvonen J, Huestis MA.
Clin Chem. 2011 Aug;57(8):1127-36. doi: 10.1373/clinchem.2011.164822. Epub 2011 Jun 15.
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178. Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease.
Sagredo O, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernández-Ruiz J.
J Neurosci Res. 2011 Sep;89(9):1509-18. doi: 10.1002/jnr.22682. Epub 2011 Jun 14.
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179. A randomized, double-blind, placebo-controlled, crossover study to evaluate the subjective abuse potential and cognitive effects of nabiximols oromucosal spray in subjects with a history of recreational cannabis use.
Schoedel KA, Chen N, Hilliard A, White L, Stott C, Russo E, Wright S, Guy G, Romach MK, Sellers EM.
Hum Psychopharmacol. 2011 Apr;26(3):224-36. doi: 10.1002/hup.1196.
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180. Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.
Klein C, Karanges E, Spiro A, Wong A, Spencer J, Huynh T, Gunasekaran N, Karl T, Long LE, Huang XF, Liu K, Arnold JC, McGregor IS.
Psychopharmacology (Berl). 2011 Nov;218(2):443-57. doi: 10.1007/s00213-011-2342-0. Epub 2011 Jun 11.
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181. Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis.
Lim MP, Devi LA, Rozenfeld R.
Cell Death Dis. 2011 Jun 9;2:e170. doi: 10.1038/cddis.2011.52.
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182. Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs.
Lafuente H, Alvarez FJ, Pazos MR, Alvarez A, Rey-Santano MC, Mielgo V, Murgia-Esteve X, Hilario E, Martinez-Orgado J.
Pediatr Res. 2011 Sep;70(3):272-7. doi: 10.1038/pr.2011.497.
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183. The role of phytochemicals in the treatment and prevention of dementia.
Howes MJ, Perry E.
Drugs Aging. 2011 Jun 1;28(6):439-68. doi: 10.2165/11591310-000000000-00000. Review.
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184. Cannabinoids and metabolites in expectorated oral fluid after 8 days of controlled around-the-clock oral THC administration.
Milman G, Barnes AJ, Schwope DM, Schwilke EW, Goodwin RS, Kelly DL, Gorelick DA, Huestis MA.
Anal Bioanal Chem. 2011 Aug;401(2):599-607. doi: 10.1007/s00216-011-5066-4. Epub 2011 Jun 3.
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185. Analysis of abuse drugs in urine using surfactant-assisted dispersive liquid-liquid microextraction.
Moradi M, Yamini Y, Baheri T.
J Sep Sci. 2011 Jul;34(14):1722-9. doi: 10.1002/jssc.201100132. Epub 2011 May 24.
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186. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
McHugh D, Page J, Dunn E, Bradshaw HB.
Br J Pharmacol. 2012 Apr;165(8):2414-24. doi: 10.1111/j.1476-5381.2011.01497.x.
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187. Cannabis with high cannabidiol content is associated with fewer psychotic experiences.
Schubart CD, Sommer IE, van Gastel WA, Goetgebuer RL, Kahn RS, Boks MP.
Schizophr Res. 2011 Aug;130(1-3):216-21. doi: 10.1016/j.schres.2011.04.017. Epub 2011 May 17.
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188. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.
Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A.
Mol Cancer Ther. 2011 Jul;10(7):1161-72. doi: 10.1158/1535-7163.MCT-10-1100. Epub 2011 May 12.
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189. Prospects for cannabinoid therapies in basal ganglia disorders.
Fernández-Ruiz J, Moreno-Martet M, Rodríguez-Cueto C, Palomo-Garo C, Gómez-Cañas M, Valdeolivas S, Guaza C, Romero J, Guzmán M, Mechoulam R, Ramos JA.
Br J Pharmacol. 2011 Aug;163(7):1365-78. doi: 10.1111/j.1476-5381.2011.01365.x. Review.
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190. Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells.
Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R, Coppola G, Geschwind D, Vogel Z.
Br J Pharmacol. 2012 Apr;165(8):2512-28. doi: 10.1111/j.1476-5381.2011.01461.x.
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191. Abuse potential and psychoactive effects of δ-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine.
Robson P.
Expert Opin Drug Saf. 2011 Sep;10(5):675-85. doi: 10.1517/14740338.2011.575778. Epub 2011 May 4. Review.
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192. The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells.
Rimmerman N, Juknat A, Kozela E, Levy R, Bradshaw HB, Vogel Z.
Cell Mol Neurobiol. 2011 Aug;31(6):921-30. doi: 10.1007/s10571-011-9692-3. Epub 2011 Apr 30.
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193. Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa.
Ruhaak LR, Felth J, Karlsson PC, Rafter JJ, Verpoorte R, Bohlin L.
Biol Pharm Bull. 2011;34(5):774-8.
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194. Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential.
Stadelmann AM, Juckel G, Arning L, Gallinat J, Epplen JT, Roser P.
Neurosci Lett. 2011 May 27;496(1):60-4. doi: 10.1016/j.neulet.2011.04.003. Epub 2011 Apr 12.
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195. A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells.
Chiba T, Ueno S, Obara Y, Nakahata N.
J Pharm Pharmacol. 2011 May;63(5):636-47. doi: 10.1111/j.2042-7158.2011.01250.x. Epub 2011 Mar 28.
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196. Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes.
Di Marzo V, Piscitelli F, Mechoulam R.
Handb Exp Pharmacol. 2011;(203):75-104. doi: 10.1007/978-3-642-17214-4_4. Review.
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197. Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol.
Hegde VL, Nagarkatti PS, Nagarkatti M.
PLoS One. 2011 Apr 1;6(4):e18281. doi: 10.1371/journal.pone.0018281.
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198. Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT(3A) receptors through a receptor desensitization-dependent mechanism.
Xiong W, Koo BN, Morton R, Zhang L.
Neuroscience. 2011 Jun 16;184:28-37. doi: 10.1016/j.neuroscience.2011.03.066. Epub 2011 Apr 6.
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199. Effect of cannabidiol in a MK-801-rodent model of aspects of schizophrenia.
Gururajan A, Taylor DA, Malone DT.
Behav Brain Res. 2011 Sep 23;222(2):299-308. doi: 10.1016/j.bbr.2011.03.053. Epub 2011 Mar 31.
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200. THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis.
Sastre-Garriga J, Vila C, Clissold S, Montalban X.
Expert Rev Neurother. 2011 May;11(5):627-37. doi: 10.1586/ern.11.47. Epub 2011 Apr 1. Review.
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CBD and Cancer

http://www.ncbi.nlm.nih.gov/pubmed/20053780

http://www.ncbi.nlm.nih.gov/pubmed/16728591

http://www.ncbi.nlm.nih.gov/pubmed/21566064

http://www.ncbi.nlm.nih.gov/pubmed/18833429

Tumor Studies:

http://www.ncbi.nlm.nih.gov/pubmed/18035205

http://www.ncbi.nlm.nih.gov/pubmed/14617682

Clinical Trials:

http://clinicaltrials.gov/ct2/results?term=cannabidiol

http://www.cannabis-med.org/studies/ww_en_db_study_search.php

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